Colleen Cutcliffe (Pendulum Therapeutics) is a doctor of biochemistry and microbiology and CEO and co-founder of Pendulum Therapeutics. Colleen joins the Armchair Expert to discuss starting a microbiome supplement company inspired by her premature daughter who had to take antibiotics, applying hyenas' evolved ability to digest rotting meat to study gut bacteria, and how fecal transplants reliably help treat C. diff. Colleen and Dax talk about the real linkages between microbiome and depression, obesity, and more, how the body’s natural GLP1s function, and why a healthy gut is a resilient gut. Colleen explains her wooden fence analogy to illustrate leaky guy syndrome, remarkable results from experiments giving mice Akkermansia, and that the beauty of the microbiome is that everything is recoverable. Watch the fact check: https://youtu.be/g3U_zxsrt9U Watch Armchair Expert episodes: https://www.youtube.com/playlist?list=PLzPEuwClyOzDdlrAmU-IwKncG87qrF7Vw Follow Armchair Expert on social: https://www.instagram.com/armchairexppod https://www.facebook.com/ArmchairExpPod/ https://twitter.com/armchairexppod Connect with Wondery https://wondery.com/shows/armchair-expert-with-dax-shepard/ https://www.facebook.com/WonderyMedia https://twitter.com/WonderyMedia https://www.instagram.com/WonderyMedia https://www.tiktok.com/@wonderymedia About the Show: Hi, I’m Dax Shepard, and I love talking to people. I am endlessly fascinated by the messiness of being human, and I find people who are vulnerable and honest about their struggles and shortcomings to be incredibly sexy. I invite you to join me as I explore other people’s stories. We will celebrate, above all, the challenges and setbacks that ultimately lead to growth and betterment. What qualifies me for such an endeavor? More than a decade of sobriety, a degree in Anthropology and four years of improv training. I will attempt to discover human “truths” without any laboratory work, clinical trials or data collection. I will be, in the great tradition of 16th-century scientists, an Armchair Expert. Watch Armchair Expert every MONDAY, WEDNESDAY, and FRIDAY here on Youtube! Listen to episodes ad-free by joining Wondery+ in the Wondery App, Apple Podcasts or Spotify. Start your free trial by visiting https://wondery.com/shows/armchair-expert-with-dax-shepard/ Chapters: 0:00 - One and a Half Generation Immigrants 10:36 - Getting Into Microbiology 13:43 - What is a Microbiome? 18:50 - Biomes in the Animal Kingdom 24:17 - Obesity and Gut Health 29:13 - What is a Healthy Gut? 37:50 - We’re Not Born with Microbes 43:40 - Breast Milk For Your Health 45:47 - Your Gut to Brain Connection 52:35 - Should People Take GLP-1s? 57:12 - Healthy Gut vs Diabetes 1:01:27 - Halle Berry’s Involvement 1:07:00 - The Product Experience #armchairexpert #daxshepard #colleencutcliffe. #microbiome