In this Huberman Lab Essentials episode, my guest is ⁠Dr. Matthew Johnson, PhD⁠, a senior researcher for the Center of Excellence for Psilocybin Research and Treatment at Sheppard Pratt’s Institute for Advanced Diagnostics and Therapeutics. We explore the science and therapeutic potential of psychedelic medicine, including psilocybin, MDMA and LSD. We discuss how these substances can profoundly alter perception and self-identity, providing long-lasting relief from depression, addiction and trauma when used in controlled clinical settings. We also discuss microdosing and emerging research on psychedelics’ potential to support recovery from neurological injuries. Episode show notes: https://go.hubermanlab.com/yjsDPfV Huberman Lab Essentials are short episodes focused on essential science and protocol takeaways from past full-length Huberman Lab episodes. Watch the full-length episode: https://youtu.be/GzvzWO0NU50 Watch more Huberman Lab Essentials episodes: https://youtube.com/playlist?list=PLPNW_gerXa4OGNy1yE-W9IX-tPu-tJa7S *Follow Huberman Lab* Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab X: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://www.hubermanlab.com Newsletter: https://www.hubermanlab.com/newsletter *Timestamps* 00:00:00 Matthew Johnson; Psychedelics 00:01:44 Different Classes of Psychedelics 00:04:33 Psychedelics & Altering Models 00:06:18 LSD, Psylocibin & Serotonin 00:08:44 Psychedelic Clinical Trials 00:12:28 Therapy, Trust, Psychedelics 00:15:36 Letting Go & Psychedelic Experience, Self-Representation, Lasting Changes 00:21:19 MDMA, Dopamine & Serotonin; Bad Trips & Transcendental Experience 00:24:43 Dangers of Psychedelics 00:27:04 Microdosing Psychedelics, Antidepressant 00:31:20 Head Injuries, Psychedelics, Depression Disclaimer & Disclosures: https://www.hubermanlab.com/disclaimer