Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional NIH grants can't fund, how their Cell Atlas became biology's missing periodic table with millions of cells catalogued in open-source format, and why their new virtual cell models will let scientists test high-risk hypotheses in silico before investing in expensive wet lab work. Plus: the organizational shift unifying the Biohub under AI leadership, what happens when biologists and engineers sit side-by-side, and why modern biology labs are expanding compute instead of square footage. Timestamps 00:00 Introduction 03:42 Building tools to accelerate scientific discovery 05:26 The credible path to funding basic science 07:03 Biohub = Frontier Biology + Frontier AI 08:58 Challenges building on a 10-15 year timeline 09:39 How CZI chooses what to work on 11:17 Making sense of science with LLMs 11:32 Measuring success in the therapeutic realm 13:32 "Most diseases should be thought of as rare diseases” 15:39 Inspiration: building a periodic table for biology 19:27 Why virtual cells? 21:17 The Biohub Master Plan 21:51 How virtual cell models allow more risk taking 28:15 Bringing CZI & Biohub together 30:32 Why Biohub matters 33:36 The importance of interface design in democratizing scientific discovery 35:34 How Biohub encourages cross-functional collaboration 40:38 Looking ahead: the broader impact of AI on biotech Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.