At the end of 2025, approximately 1 in 8 adults (about 12%) reported currently using a glucagon-like peptide-1 (GLP-1) drug. In this episode of the podcast, Geoff Cook, CEO of Noom, and I engage in a nuanced, science-forward conversation about GLP-1 medications—and why the future of these compounds may look very different from the way they’re being used today. In this episode, we cover: - What Noom actually is and how they’re approaching preventive health and longevity - What it really means to “microdose” a GLP-1 and how that differs from standard dosing - How GLP-1s can support inflammation reduction and insulin sensitivity—beyond weight loss - The potential impacts on brain health, cravings (including alcohol-related cravings), and behavior change - What fertility considerations look like with GLP-1 use, including implications for polycystic ovary syndrome (PCOS) - Which biomarkers you can track to assess whether a GLP-1 is actually working - How peptide safety and pharmacy standards are determined, and how Noom is navigating the current regulatory landscape This is a must-listen for anyone curious about GLP-1s but cautious about side effects, long-term safety, or the “one-size-fits-all” approach that dominates the conversation. LIFE Network: https://joinlifenetwork.com Ben Greenfield Life Website: https://bengreenfieldlife.com/ Ben Greenfield Life Podcast: https://bengreenfieldlife.com/podcast/ Ben Greenfield Books: https://shopbengreenfieldlife.com/collections/books Instagram https://www.instagram.com/bengreenfieldfitness/ Facebook https://www.facebook.com/BGFitness X https://twitter.com/bengreenfield TikTok https://www.tiktok.com/@bengreenfield 00:00 "GLP1, Peptides, & Microdosing" 05:21 Microdosing Retatrutide for Appetite 09:15 GLP1s: Regulation and Accessibility 11:25 "FDA's Compounding Quality Initiative" 14:35 "Appetite Suppression and Microdosing" 18:26 "Microdose Habits vs. Dependency" 20:51 "Building Habits Through Structure" 26:25 Inflammation, Fat Loss, Brain Health 27:47 "Food Noise and Cognitive Bandwidth" 32:22 "503A Compliance & Microdosing Protocol" 34:45 Precise Peptide Dosing Importance 39:42 Inflammation, Cholesterol, Testosterone, TASO. 42:35 "Drug Pricing and Access Issues" 46:15 Affiliate Disclosure and Transparency 47:01 "Optimizing Mind, Body, Spirit"