This episode is a spectacular round two podcast with Dr. Valter Longo. Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy. Dr. Longo’s research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human age-related diseases, including those of autoimmune origin and cancer. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/valter-longo-2?utm_source=youtube&utm_medium=youtube&utm_campaign=longo-2_interview "The Longevity Diet" Book: https://amzn.to/2zvxz8n Dr. Longo's faculty page: https://gero.usc.edu/faculty/longo/ ProLon FMD: http://www.prolonfmd.com/ PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=longo-2_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/042-dr-valter-longo-on-resetting-autoimmunity-and/id818198322?i=1000532219809 Spotify: https://open.spotify.com/episode/1epXwEiTwN3AWyoJmOEpmC Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi Chapters 00:00:00 - Introduction 00:01:00 - Defining fasting 00:04:48 - Caloric restriction in monkeys 00:06:40 - IGF-1 & mTOR 00:11:48 - Laron's syndrome 00:14:20 - Fasting in other species 00:21:25 - Cancer 00:30:44 - Fasting-mimicking diet 00:38:57 - "Yo-yo" diet 00:42:49 - Muscle mass 00:47:33 - Apoptosis 00:53:04 - Refeeding 00:56:02 - Biomarkers for health SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=longo-2_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=longo-2_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d