Dr. Valter Longo, Director of USC's Longevity Institute and one of TIME's 50 most influential people in healthcare, reveals the mechanistic power of therapeutic fasting. We discuss his groundbreaking Fasting Mimicking Diet, its implications for cancer treatment, disease reversal, and extending human healthspan. READ MORE👉🏾 https://bit.ly/richroll889 ✌🏼🌱 - Rich This Episode Is Brought To You By… Seed: Use code RICHROLL25 to get 25% off your first month 👉https://bit.ly/seedxrrp2025 Squarespace: Use code RichRoll to save 10% off 👉https://bit.ly/squarespace2025 BetterHelp: Use the code RICHROLL to get 10% off your first month 👉BetterHelp.com/richroll On: High-performance shoes & apparel crafted for comfort and style 👉on.com/richroll Check out all of the amazing discounts from our Sponsors 👉🏾 https://bit.ly/rrpsponsors LISTEN / SUBSCRIBE TO THE PODCAST Apple Podcasts: http://bit.ly/rrpitunes Spotify: http://bit.ly/rrpspotify Google: http://bit.ly/rrpgooglepods Meal Planner: http://meals.richroll.com Voicing Change Book: http://richroll.com/vc Clips Channel: https://www.youtube.com/c/RichRollPodcastClips Newsletter: http://bit.ly/rollcallemail CHAPTERS 00:00:00 Intro 00:03:54 Funding for Research and Clinical Trials 00:05:29 Role of NIH in Research and Clinical Trials 00:06:45 Latest Findings on Fasting and Time-Restricted Eating 00:07:21 Efficacy of 12-Hour Fasting Window 00:10:31 Fasting-Mimicking Diet 00:11:54 Understanding Time-Restricted Eating 00:13:27 Impact of Eating Habits on Sleep 00:16:36 Exploration of Calorie Restriction and Fasting-Mimicking Diet 00:17:50 The Longevity Diet and Comparing Different Diets 00:18:29 Understanding the Impact of Individual Food Items 00:20:03 Role of Genetics in Diet and Aging 00:21:52 Potential of Fasting-Mimicking Diet in Disease Treatment 00:26:03 Understanding the Mechanisms of Fasting Diets 00:27:42 Metabolic Switches and Energy Modes 00:29:56 Challenges in Weight Loss and Energy Saving Mode 00:33:17 Ad Break 00:35:21 Role of Fasting-Mimicking Diet in Disease Reversal 00:36:06 Fasting-Mimicking Diet and Regeneration of Immune System 00:41:17 Applicability of Animal Studies to Human Biology 00:45:05 Receptivity of Traditional Medical Community to Fasting Diets 00:46:07 The Connection Between Aging and Chronic Diseases 00:47:51 Fasting-Mimicking Diet and Bone Density 00:48:10 Fasting-Mimicking Diet and Muscle Mass 00:49:50 Combining Fasting-Mimicking Diet with GLP-1 00:51:37 Combining Fasting-Mimicking Diet with Liraglutide 00:54:23 The Importance of Effort and Discomfort in Achieving Health Goals 00:58:28 The Growing Interest in Healthspan Extension and Longevity Medicine 00:59:44 The Role of Protein in the Longevity Diet 01:01:51 Understanding Protein Intake and Aging 01:03:30 Role of Amino Acids in Aging and Health 01:05:36 Impact of Protein Pathway on Aging 01:06:56 The Detrimental Effects of High Protein Diet 01:09:43 The Importance of Balanced Amino Acid Intake 01:11:17 Practical Implementation of Balanced Protein Intake 01:13:42 Ad Break 01:16:05 Discussion on Brian Johnson's Blueprint Protocol 01:18:27 Risks and Uncertainties of Unconventional Diets and Supplements 01:23:27 The Misconceptions of Short-Term Effects of Diets 01:26:17 The Role of Genetics in Diet and Longevity 01:27:59 The Complexity of Cancer and the Role of Fasting-Mimicking Diet 01:29:50 The Potential of Fasting-Mimicking Diet in Cancer Treatment 01:35:58 The Potential of Fasting-Mimicking Diet in Various Cancer Treatments 01:42:43 Mechanism of Fasting-Mimicking Diet in Cancer Treatment 01:45:39 The Message of the Book: Cancer Prevention and Treatment 01:47:29 The Role of AI in Identifying Escape Pathways and Drugs 01:49:18 Concerns and Potential Dangers of AI 01:51:30 The Need for Regulation of AI 01:54:30 Comparing AI with Nuclear Power CONNECT WITH RICH ✩ Website - http://richroll.com​ ✩ Rich Roll Podcast - https://richroll.com/all-episodes/ ✩ Instagram - https://www.instagram.com/richroll/ ✩ Twitter - https://twitter.com/richroll ✩ Facebook - https://www.facebook.com/richrollfans ✩ Strava - https://www.strava.com/athletes/14443?oq=rich ✩ Memoir: Finding Ultra - https://www.richroll.com/shop/books/finding-ultra/ ✩ Meals - http://meals.richroll.com​ ✩ Cook - The Plantpower Way - https://www.richroll.com/shop/books/the-plantpower-way-signed/ ✩ Italian! - The Plantpower Way: Italia - https://www.richroll.com/shop/books/the-plantpower-way-italia-signed/ ✩ Support - https://www.patreon.com/richroll FILMED AND EDITED BY DAN DRAKE https://www.dandrake333.com/ * * * * * NEW TO RICH? Hi I'm Rich Roll. I'm a vegan ultra-endurance athlete, author, podcaster, public speaker & wellness evangelist. But mainly I'm a dad of four. If you want to know more, visit my website or check out these two the NY Times articles: http://bit.ly/otillonyt http://bit.ly/vegansglam I LOVE MAIL! SEND IT HERE: 2630 Conejo Spectrum St. Thousand Oaks, CA 91320 #richroll #richrollpodcast