Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Original release date: 11/25/19 In this episode, Dr. Debra Kimless and Steve Goldner share their knowledge on the science, policy, and market evolution of medicinal cannabis. We start with the differences between THC and CBD, how they work in the body, and how they act on the brain. We discuss the many potential benefits of using CBD, THC, hemp in the various forms of administration (smoking, vaping, edibles, oils, etc.) as well as some of the safety issues including the recent uptick in incidents of hospitalization and death linked to vaping. Debra and Steve are both involved with the company, Pure Green—Debra the Chief Medical Officer and Steve the founder and CEO—whose aim is to create the safest, most efficacious form of delivery of cannabis. Their bigger mission is to shift the perception of the cannabis plant, garner acceptance of its medicinal benefits, and ultimately get it descheduled on a federal level so more people can access cannabis for a range of chronic ailments. We discuss: -Debra and Steve’s background reason for their interest in medical cannabis [7:00]; -The history of medical use of cannabis [11:15]; -How THC, CBD, and other cannabinoids work [16:00]; -Hemp—What it is, special uses, and the 2018 farm bill [22:45]; -The legal status of CBD, Deb and Steve’s clinical trial, and how CBD differs from THC [30:15]; -The safety profile of THC [35:00]; -Is marijuana as a gateway drug? [45:30]; -Smoking vs. vaping vs. edibles—Benefits, risks, and mechanistic differences [53:30]; -Can you build up a tolerance to the effects of THC? [1:15:00]; -What do people generally want to get from using marijuana? [1:17:15]; -Cannabinoid synthetics [1:22:30]; -Efficacy of CBD oils as a sleep aid [1:25:00]; -Pure Green Cannabis [1:30:30]; -Anecdotal evidence and managing the hype surrounding cannabis in medical treatment [1:38:45]; -Aspirations for the future of medicinal cannabis, and the legal challenges that await them [1:45:15]; -Descheduling cannabis: A human rights issue [2:04:00] and; -More. Show notes page: https://peterattiamd.com/debrakimless-stevegoldner/ -------- About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Podcasts: http://bit.ly/TheDriveGoogle