Dr. Jeffrey Goldberg is Professor and Chair of Ophthalmology and Director of the Byers Eye Institute at Stanford University, a leading scientist in the development and degeneration of the visual system from eye to brain, and a practicing ophthalmologist and surgeon. This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (Use code TIM at checkout for 30% off any plan.) Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off on all mattress orders.) AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Tim Ferriss is one of Fast Company’s “Most Innovative Business People” and an early-stage tech investor/advisor in Uber, Facebook, Twitter, Shopify, Duolingo, Alibaba, and 50+ other companies. He is also the author of five #1 New York Times and Wall Street Journal bestsellers: The 4-Hour Workweek, The 4-Hour Body, The 4-Hour Chef, Tools of Titans and Tribe of Mentors. The Observer and other media have named him “the Oprah of audio” due to the influence of his podcast, The Tim Ferriss Show, which has exceeded 900 million downloads and been selected for “Best of Apple Podcasts” three years running. Sign up for "5-Bullet Friday" (Tim's free weekly email newsletter): https://go.tim.blog/5-bullet-friday-yt/ Follow the Tim Ferriss Podcast: https://tim.blog/podcast/ Visit the Tim Ferriss Blog: https://tim.blog/ Follow Tim Ferriss on Twitter: https://twitter.com/tferriss/ Follow Tim Ferriss on Instagram: https://www.instagram.com/timferriss/ Like Tim Ferriss on Facebook: https://www.facebook.com/TimFerriss/ [00:00] Start. [00:36] How do you solve a problem like presbyopia? [04:01] The athletic benefits of training supranormal (better than 20/20) vision. [07:07] Indigenous eye drops and FDA-approved pilocarpine for presbyopia. [09:24] Understanding basic eye anatomy. [12:44] Exploring AREDS 2, CoQ10, ginkgo, vitamin B3, and other supplements for vision. [18:25] Visual training devices and psychedelic-prompted brain plasticity. [20:37] Thoughts on visual training effectiveness and motor action requirements. [24:03] Concussion rehabilitation and visual perception exercises. [26:59] Red light and violet light therapy for myopia and mitochondrial health. [30:30] Vision loss correlation with cognitive decline and depression. [34:05] Presbyopia progression and psychological dependence on readers. [35:44] Cognito Therapeutics headset for Alzheimer's treatment. [41:20] Glaucoma basics: neurodegenerative disease and risk factors. [43:30] Eye pressure variability and diurnal cycles. [44:37] Cannabis effects on eye pressure and compound isolation. [46:21] Stem cell research for vision restoration. [47:45] Anti-inflammatory effects and immune system role in eye diseases. [49:51] Gut microbiome connection to glaucoma in animal models. [53:38] Metabolic syndrome and GLP-1 receptor agonists. [55:52] Microbiome sharing and future therapeutic possibilities. [58:16] Dry eye treatment: preservative-free tears and serum drops. [01:03:37] Vision screening recommendations and UV protection. [01:06:20] Full-spectrum light benefits vs. UV exposure. [01:08:24] Paradigm shifts: irreversible vision loss becoming reversible. [01:12:20] Convergence of neuroscience advances and biotech investment. [01:17:08] Miraculous mitochondria: health, transplants, and three-parent babies. [01:21:39] My family history concerns and metabolic health screening. [01:24:59] Exercise's biggest gain: going from none to some. [01:28:34] Clinical trial participation resources and parting thoughts.