@PeterAttiaMD is a highly respected expert in preventive medicine with a special focus on the applied science of longevity. His deep engagement with the topic of longevity is the cornerstone of his NY Times bestselling book, 'Outlive: The Science and Art of Longevity'. Dr. Attia also extends his expertise into his clinical practice Early Medical and shares his knowledge through his popular podcast many of you are already aware of, 'The Drive.' EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/peter-attia-2?utm_source=youtube&utm_medium=youtube&utm_campaign=peter_attia_podcast Dr. Peter Attia on Twitter: https://twitter.com/PeterAttiaMD Dr. Peter Attia on Instagram: https://www.instagram.com/peterattiamd Dr. Peter Attia's Website: https://peterattiamd.com The Drive Podcast: https://podcasts.apple.com/us/podcast/the-peter-attia-drive/id1400828889 "Outlive: The Art and Science of Longevity" Book: https://www.amazon.com/Outlive-Longevity-Peter-Attia-MD/dp/0593236599 CHAPTERS: (00:00:00) In this episode (00:04:29) Defining cardiovascular disease (00:06:36) Coronary plaque and fatality risk (00:08:02) What is cholesterol? (00:10:27) How ApoB predicts heart disease (00:18:27) Factors elevating ApoB (00:22:17) ApoB reference range explained (00:24:16) Does high ApoB cause cardiovascular disease (00:33:54) ApoB thresholds for ASCVD prevention (00:37:20) Dietary factors raising ApoB (00:36:26) Genetics of ApoB and LDL (00:50:17) Does low LDL increase cancer? (00:53:12) Cholesterol-lowering drugs (00:56:52) Statins, uses, and side effects (01:00:05) Are statins toxic to mitochondria? (01:06:49) Ubiquinol for statin-induced muscle soreness (01:08:02) How to train in zone 2 (01:14:02) Statins and neurodegenerative disease risk (01:18:47) Cholesterol synthesis in the brain (desmosterol role) (01:22:51) Statin alternatives – pros and cons (01:24:23) Ezetimibe (01:27:54) Bempedoic acid (01:33:42) Berberine for CVD Risk Reduction? (01:36:29) Muscle as a glucose sink (01:42:51) Chronic glucose toxicity and vascular impact (01:48:31) Hemoglobin A1C Levels and Mortality Data (01:52:28) 80/20 Zone 2/VO2 Max Training Protocol (01:59:05) Insights from VO2 max testing data (02:09:10) How obesity increases cancer risk (02:11:56) Cancer screening benefits and risks (02:17:40) Dr. Attia's recommended cancer screening age (02:25:47) Liquid biopsies for detecting cancer (02:31:41) CT scans, mammograms and radiation concerns (02:37:25) Menopause – hormonal shifts and health effects (02:42:06) Hormone replacement therapy (HRT) (02:55:50) Perimenopause diagnosis with hormone levels (02:58:57) HRT's impact on dementia, cancer, and heart disease risk (03:01:42) Estrogen's role in bone density (03:04:35) Vitamin D (03:13:17) Testosterone replacement for women's sexual function (03:15:40) HRT safety 10 years post-menopause (03:19:58) Treating low testosterone in men (03:26:46) TRT side effects and risks (03:29:26) Ways to reduce blood pressure (03:36:26) How to measure blood pressure (03:42:23) Peter's longevity optimization routines PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=peter_attia_podcast Apple Podcasts: https://podcasts.apple.com/us/podcast/085-dr-peter-attia-on-mastering-longevity-insights/id818198322?i=1000639831254 Spotify: https://open.spotify.com/episode/6vVH3agWalaicr6ZINcyYA?si=b3e4c16bdaeb4724 RSS: https://podcast.foundmyfitness.com/rss.xml Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi SUPPORT THE CHANNEL: Premium subscribers of FoundMyFitness get access to a Google Presentation for the graphics in videos, earlier access, a two-times-per-month science news digest and commentary, and some kind of live online event usually every month. Learn more at: https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=peter_attia_podcast Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness #longevity #healthspan #antiaging