Today we're back, for a third podcast, with long time friend of the pod, Dr. Michael Hughes - a biochemist at St. Jude's Research Hospital in Memphis, TN. We plunge into the secret story of water, revealing its role as more than a silent spectator in the dance of cellular processes. Like a conductor in an unseen ballet, water’s dynamic and nuanced structures orchestrate communication across cells, acting as a transient computationally competent actuator. Michael reveals how much of this story has been buried for years under blanket abstractions like "pH" and electrochemistry. We see the emergence of a new paradigm in cellular computation, as we uncover how water may not just be the medium of life — at times it’s perhaps every bit as alive as we are. PATREON: get episodes early + join our weekly Patron Chat https://bit.ly/3lcAasB MERCH: Rock some DemystifySci gear : https://demystifysci.myspreadshop.com/ AMAZON: Do your shopping through this link: https://amzn.to/3YyoT98 References from Michael: Na+ vs K+ water dynamics: https://pubs.rsc.org/en/content/articlelanding/2017/sc/c6sc03320b ; https://pubmed.ncbi.nlm.nih.gov/23713450/ Ion pairing & Collins’ Law of water affinity: https://doi.org/10.1017/S0033583519000106 Kosmotropes/Chaotropes ion pairing in biochemistry review: https://pmc.ncbi.nlm.nih.gov/articles/PMC4693242/ Osmotic pressure influences stem cell differentiation: https://www.pnas.org/doi/10.1073/pnas.1705179114 Hydration as a primary factor in carcinogenesis: https://pubmed.ncbi.nlm.nih.gov/16271440/ Distinguishing electrical properties of cancer cells: https://www.sciencedirect.com/science/article/abs/pii/S157106452200063X Heart is not a pump: https://rsarchive.org/OtherAuthors/MarinelliRalph/marinelli1.html Laszlo Boros water metabolism: https://www.youtube.com/watch?v=0g8OLChXta8 Challenging Misconceptions about Osmosis: https://www.ableweb.org/biologylabs/wp-content/uploads/volumes/vol-30/006.pdf "memory of ice phases" in liquid water involves Ice V and Ice III. Other proposed memory effects detailed here: https://agupubs.onlinelibrary.wiley.com/doi/pdf/10.1029/2011GL048217 00:00 Go! 00:09:24 Revisiting Water's Unknowns in Biology 00:22:44 Osmotic Pressure as Dark Matter 00:25:31 Nature of Osmotic Pressure 00:30:38 Water Molecule Interactions 00:35:37 Collective Motion and Electricity 00:42:20 Water’s Role in Life and Science 00:44:35 Memory of Water, for Real 00:48:09 Disappearing Polymorphs and Chemical Synthesis 00:51:05 Understanding Water Freezing and Supercooling 00:54:34 Biochemistry and Protein Folding 00:59:05 pH, Charge, and Biological Systems 01:08:38 Tetrahedral Ordering in Water Structures 01:17:01 Energy Transfer and Cellular Connectivity 01:27:54 Understanding Proton Channels and Aquaporins 01:30:00 Back to pH 01:39:10 Cosmotropes and Chaotropes 01:49:57 Ion Dynamics in Cells 01:57:15 Unconventional Views on Consciousness and Physiology #water , #structuredwater , #paradigmshift , #Biochemistry, #ScienceExplained, #Electrochemistry, #NewParadigm, #WaterInBiology, #CellularCommunication, #PhaseTransitions, #Biophysics, #MolecularScience, #SciencePodcast, #ScientificBreakthrough, #WaterStructure, #EmergingScience, #CellBiology, #BiochemicalMysteries, #pHExplained, #scientificinnovation #sciencepodcast, #longformpodcast Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671