Just weeks after the genome sequence of the recently emerged coronavirus was published online, researchers reported the cryogenic electron microscopy structure of the spike protein the virus uses to gain entry to host cells in a 19 February Science paper (https://scim.ag/2WxQ8lY). The insights from their study are already helping to inform vaccines against SARS-CoV-2. On Friday, the coauthors of this study, Jason McLellan and Barney Graham, discussed via Facebook Live how they visualized the spike protein, as well as how their work to improve understanding of SARS-CoV2 viral structure will inform therapeutics against this virus going forward.