Full Show Notes: https://bengreenfieldlife.com/nadplus In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology. You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD. You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging. Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline. Timestamps 0:00 What is NAD? 0:38 Guest intro: Dr. Nicola Conlon 1:05 Why NAD supplements don't say "NAD" on the label 2:12 How NAD works in the body 6:30 The NAD salvage pathway 10:29 Why NAD declines with age 13:40 Why NR & NMN aren't enough 16:06 NAD & sleep / circadian rhythm 19:25 CD38: the biggest NAD drain 20:57 Are NAD IVs worth it? 23:15 NAD IVs may cause inflammation 26:32 The methylation problem with high-dose NR/NMN 32:13 Introducing Nuchido TIME+ 35:10 Why nicotinamide beats NR & NMN 36:39 Rutin & ALA — reactivating NAMPT 37:35 Apigenin — inhibiting CD38 40:20 EGCG — fixing the methylation problem 42:46 Human clinical trial results 45:32 Biological age reversal: 1.26 years in 28 days 48:55 Daily dosing vs. pulsing 54:08 Where to learn more 📲 Check out my FREE Top Health Community! - https://joinlifenetwork.com 💊Shop My Curated Marketplace of Vetted Products! - https://shoplifemarket.com 🏋️Sign up for a FREE Coaching Call! - https://jointriumphcoaching.com 📩 Check out my FREE newsletter! - https://bengreenfieldlife.com/newsletter/ 🔗My Website: https://bengreenfieldlife.com/ 🔗My Podcast: https://bengreenfieldlife.com/podcast/ 🔗My Books: https://shopbengreenfieldlife.com/collections/books Connect with me: ⬇️ Instagram https://www.instagram.com/bengreenfieldfitness/ Facebook https://www.facebook.com/BGFitness X https://twitter.com/bengreenfield TikTok https://www.tiktok.com/@bengreenfield