Sam Altman has led OpenAI from its founding as a research nonprofit in 2015 to becoming the most valuable startup in the world ten years later. In this episode, a16z Cofounder Ben Horowitz and General Partner Erik Torenberg sit down with Sam to discuss the core thesis behind OpenAI’s disparate bets, why they released Sora, how they use models internally, the best AI evals, and where we’re going from here. Timecodes: 0:00 Introduction 0:41 OpenAI’s Vision and Infrastructure 2:37 Business Model and Vertical Integration 5:08 AGI, Sora, and Societal Co-evolution 8:01 The Future of AI Interfaces 9:12 AI Scientists and Scientific Progress 11:44 Reflections on Progress and Model Capabilities 16:17 Sam's Experience as CEO & Leadership Lessons 17:34 Strategic Partnerships and Scaling Infrastructure 25:05 Regulation, Safety, and Societal Impact 28:33 Copyright, Open Source, and Content Creation 33:15 Energy, Policy, and AI’s Resource Needs 37:07 Monetization and User Behavior 43:03 The Talent War and Personal Reflections 45:20 Advice for Founders Resources: Follow Sam on X: https://x.com/sama Follow OpenAI on X: https://x.com/openai Learn more about OpenAI: https://openai.com/ Try Sora: https://sora.com/ Follow Ben on X: https://x.com/bhorowitz Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your friends! Find a16z on X: https://x.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Listen to the a16z Podcast on Spotify: https://open.spotify.com/show/5bC65RDvs3oxnLyqqvkUYX Listen to the a16z Podcast on Apple Podcasts: https://podcasts.apple.com/us/podcast/a16z-podcast/id842818711 Follow our host: https://x.com/eriktorenberg Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details, please see a16z.com/disclosures.