What happens when the FDA approves a drug that doesn't work? Say it gets accelerated approval from the regulatory body, but further clinical trials demonstrate a lack of efficacy. Normally, the agency requests that the company take their drug off the market, the company does so, and so the wheel turns. But when post-approval clinical trials showed that Genentech's blockbuster breast cancer drug Avastin was killing women, the company broke with more than a century of tradition, and declined to take their drug off the market. We talk with Miami University's Mikkael Sekeres about his experience sitting on the jury for the trial that denied Genentech's right to keep selling Avastin to breast cancer patients, regulatory capture, care for the dying, gamesmanship at the FDA and much, much more. Support the scientific revolution with a monthly donation: https://bit.ly/3lcAasB Or buy Dr. Sekeres' book, Drugs and the FDA: https://amzn.to/3QuIiUk As always, let us know what you think in the comments! 00:00 Go! 00:03:47 Challenges of getting science to the people 00:08:14 The marriage of medicine to industry 00:23:46 The Metrics of Health 00:37:11 Remission vs Life Extension 00:45:05 The Promise of Medicine 00:54:20 Predicting Outcomes 00:59:55 Carrying the Weight of Death 01:05:46 The Philosophical Effects of Care 01:10:21 Why Oncology? 01:16:02 Successes of Palliative Therapy 01:22:57 Gamesmanship at the FDA 01:31:09 Conflicts of Interest 01:44:35 Insurance 01:50:29 Facing the Real World 01:56:43 Culture 02:01:18 The Path Forward #medicine #fda #cancer Check our short-films channel, @DemystifySci: https://www.youtube.com/c/DemystifyingScience AND our material science investigations of atomics, @MaterialAtomics https://www.youtube.com/@MaterialAtomics Join our mailing list https://bit.ly/3v3kz2S PODCAST INFO: Anastasia completed her PhD studying bioelectricity at Columbia University. When not talking to brilliant people or making movies, she spends her time painting, reading, and guiding backcountry excursions. Michael Shilo also did his PhD at Columbia studying the elastic properties of molecular water. When he's not in the film studio, he's exploring sound in music. They are both freelance professors at various universities. - Blog: http://DemystifySci.com/blog - RSS: https://anchor.fm/s/2be66934/podcast/rss - Donate: https://bit.ly/3wkPqaD - Swag: https://bit.ly/2PXdC2y SOCIAL: - Discord: https://discord.gg/MJzKT8CQub - Facebook: https://www.facebook.com/groups/DemystifySci - Instagram: https://www.instagram.com/DemystifySci/ - Twitter: https://twitter.com/DemystifySci MUSIC: -Shilo Delay: https://g.co/kgs/oty671