This episode features Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. In this nearly 45-minute conversation, we talk about... • The importance of time-restricted eating as a practical public health intervention, mostly for it's ease of implementation, that may have a widespread impact on disease risk. • Why you should probably make sure your time-restricted eating window occurs earlier in the day, rather than later. • How the first 5% drop in weight loss can have disproportionately large effects on the metabolic factors associated with breast cancer risk when compared with subsequent weight loss. • The association of longer fasting durations beginning earlier in the evening and improved sleep in humans, as well as spontaneous physical activity in their day-to-day lives. • The relationship between metabolism and breast cancer risk. • The effect of lifestyle factors, such as obesity, physical activity, what and even when you eat, whether or not you smoke tobacco... and how even modest changes, such as consuming food earlier in the day and only during an 11-hour window, can decrease breast cancer risk and recurrence by as much as 36%. • The importance of starting your fast earlier in the evening, and how an earlier eating window has been shown to correlate to reductions in inflammatory markers. • The association of higher circulating insulin levels with breast cancer risk, and how insulin itself has an important relationship with estrogen by affecting the levels of sex-hormone binding globulin. • The dangers of having a cellular environment that is inflamed, as the case is with the obese, and simultaneously having elevated cellular growth signals, which is also characteristic of the hormonal milieu of the obese. • The surprisingly small role heredity plays in determining overall risk of breast cancer when compared to lifestyle factors. • How healthful lifestyle habits, like choosing to eat during the right window, ultimately helps us trend our risk for many of the diseases of old age in the correct direction instead of influencing only one or another. EPISODE LINKS: Show notes and transcript: https://www.foundmyfitness.com/episodes/ruth-patterson?utm_source=youtube&utm_medium=youtube&utm_campaign=patterson_interview Learn more about Dr. Ruth Patterson: https://ph.ucsd.edu/jdp/directory/faculty/patterson.html PODCAST INFO: Email: https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=patterson_interview Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322?i=1000532219465 Spotify: https://open.spotify.com/episode/06qjYOSlN6qry5kmHvwvLY?si=w4VVz2KRQYarU4JRtCsXeA&nd=1 Full interview playlist: https://www.youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s Clips playlist: https://www.youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi Chapters: 00:00:00 - Introduction 00:00:15 - Modifiable risk factors for breast cancer 00:03:33 - Hormones 00:07:45 - Circadian rhythm 00:10:56 - Time-restricted eating 00:14:05 - Decreased breast cancer recurrence 00:19:30 - Hemoglobin A1C 00:24:50 - Metabolic "rest" 00:27:15 - Meal frequency 00:31:31 - Sleep 00:34:53 - Genetic risk factors for breast cancer 00:38:21 - Summary SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER: Receive emailed episode notifications and regular updates on the emerging science of healthspan. https://www.foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=patterson_interview SUPPORT THE CHANNEL: Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at https://www.foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=patterson_interview Thank you for watching! SOCIALS: https://twitter.com/foundmyfitness https://facebook.com/foundmyfitness https://instagram.com/foundmyfitness PODCAST: Apple Podcasts: https://podcasts.apple.com/us/podcast/foundmyfitness/id818198322 Spotify: https://open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d