In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.’ I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood. #HubermanLab #Bipolar #BipolarDisorder Thank you to our sponsors InsideTracker: https://insidetracker.com/huberman ROKA: https://www.roka.com/huberman Blinkist: https://www.blinkist.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman Social & Website Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab TikTok - https://www.tiktok.com/@hubermanlab Website - https://hubermanlab.com Newsletter - https://hubermanlab.com/neural-network Subscribe to the Huberman Lab Podcast Apple Podcasts: https://apple.co/3thCToZ Spotify: https://spoti.fi/3PYzuFs Google Podcasts: https://bit.ly/3amI809 Other platforms: https://hubermanlab.com/follow Full show notes & links to peer-reviewed articles: https://hubermanlab.com/the-science-and-treatment-of-bipolar-disorder Timestamps 00:00:00 Bipolar Disorder 00:02:23 Momentous Supplements 00:03:42 Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate 00:10:23 InsideTracker, ROKA, Blinkist 00:14:24 Prevalence & Severity of Bipolar Disorder 00:16:30 Bipolar Disorder I, Diagnostic Criteria of Mania 00:28:58 Bipolar Disorder II, Individual Variability 00:33:07 Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States 00:38:20 Consequences of Bipolar Disorder, Heritability 00:46:53 Bipolar Disorder vs. Borderline Personality Disorder 00:51:51 Mania & Depression, Negative Impacts 00:53:06 History of Lithium Treatment 01:02:44 Lithium Treatment & Side-Effects 01:05:05 Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection 01:10:10 Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity 01:17:11 Neural States & Mania, Parietal Lobe & Limbic System 01:22:58 Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine 01:36:00 Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy 01:43:18 Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS) 01:48:01 Psylocibin, Cannabis 01:51:50 Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids 02:03:31 Omega-3s, Membrane Fluidity & Neuroplasticity 02:06:44 Mania, Creativity & Occupations 02:15:33 Bipolar Disorder: Diagnosis, Neural Circuits & Treatment 02:17:45 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions. Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com