Show Notes: 00:00 Cold Open 01:19 Bestie banter & poker recap 04:24 Supply chain challenges in Los Angeles 8:53 The Fed, interest rates and inflation 34:04 Geopolitical storm-clouds, deflationary tools 43:11 Why Sacks is hosting a fundraiser for Florida Governor DeSantis 47:00 Ted Sarandos responds to Netflix employees, 55:31 Cancel culture’s lifespan, book recommendations 1:02:34 Tether 01:08:24 The FDA’s new ruling on Aspirin, what this means for science 01:23:27 Fan Question 1 from Daniel on Twitter about Alphafold 01:27:08 Fan Question 2 from Maddie on Twitter about career advice Follow the besties: https://twitter.com/chamath https://linktr.ee/calacanis https://twitter.com/DavidSacks https://twitter.com/friedberg Follow the pod: https://twitter.com/theallinpod https://linktr.ee/allinpodcast Intro Music Credit: https://rb.gy/tppkzl https://twitter.com/yung_spielburg Intro Video Credit: https://twitter.com/TheZachEffect Referenced in the show: Statista - The U.S. Car Models Most Impacted By The Microchip Shortage https://www.statista.com/chart/24969/vehicles-taken-out-of-production-due-to-microchip-shortages Zack Kanter on Twitter - "The “supply chain crisis” is a clever rebrand" https://twitter.com/zackkanter/status/1447376938805432321 Naithan Jones on Twitter - NFTs https://twitter.com/NaithanJones/status/1448989717756850179 Daily Breeze - No start date for 24/7 operations at Port of LA https://www.dailybreeze.com/2021/10/14/no-timetable-yet-for-port-of-las-24-7-operations-but-talks-ramping-up-officials-say/ LA Daily News - Port of LA to go to 24/7 operations, Biden announces https://www.dailynews.com/2021/10/13/biden-to-announce-that-ports-of-la-long-beach-will-begin-24-hour-operation/ Nikkei Asia - TSMC announces plans to build first chip plant in Japan https://asia.nikkei.com/Business/Tech/Semiconductors/TSMC-announces-plans-to-build-first-chip-plant-in-Japan St. Louis Fed - Total Public Debt as Percent of Gross Domestic Product https://fred.stlouisfed.org/series/GFDEGDQ188S Forbes - Druckenmiller Blasts Fed’s ‘Radical’ Stimulus Policy https://www.forbes.com/sites/jonathanponciano/2021/05/11/billionaire-investor-druckenmiller-blasts-feds-radical-stimulus-policy-warns-it-risks-stock-bubble-blowing-up/?sh=2a9866e82fe8 David Sacks on Twitter - Desantis Dinner https://twitter.com/DavidSacks/status/1447780027110617089 Variety - Ted Sarandos Doubles Down https://variety.com/2021/film/news/ted-sarandos-dave-chappelle-defense-1235088647/ The Light of Other Days by Arthur C. Clarke https://www.amazon.com/Light-Other-Days-Arthur-Clarke/dp/0312871996 CFTC Orders Tether and Bitfinex to Pay Fines Totaling $42.5 Million https://www.cftc.gov/PressRoom/PressReleases/8450-21 NBC - Most adults shouldn't take daily aspirin https://www.nbcnews.com/health/heart-health/adults-shouldnt-take-daily-aspirin-prevent-heart-attack-panel-says-rcna2869 Botched - Man Wins $100,000 Breast Implants Bet! https://www.youtube.com/watch?v=626ZaH9ZuPs Audience Question 1 - Daniel on Twitter, Alphafold https://twitter.com/daniel_nelis/status/1449055005181415424?s=20 Audience Question 2 - Maddie on Twitter, Career advice https://twitter.com/Maddiechavs/status/1448863457965531146?s=20 #allin #tech #news