Sign up to receive Peter's email newsletter: https://bit.ly/4c602k2 Peter is joined by writer, director, actress, and founder of HFC, Lauren Miller Rogen, and previous podcast guest and director of the Alzheimer’s Prevention Clinic at Weill Cornell Medicine and New York-Presbyterian, Dr. Richard Isaacson. In this episode, Lauren tells the heartbreaking story of watching members of her family succumb to Alzheimer’s disease (AD) which motivated her to proactively address her own risk with Richard’s guidance. Richard discusses the various genetic and lifestyle factors that influence the risk of AD and uses Lauren’s unique situation to explain how he diagnoses patients and personalizes care. They go through Lauren’s protocol of preventative measures that have already produced marked results, and end with the uplifting message that one’s genetic predisposition does not seal one's fate. We discuss: 00:00:00 - Intro 00:03:10 - Lauren’s deep family history of Alzheimer’s disease 00:13:45 - The influence of genetics, epigenetics, and lifestyle on Alzheimer’s disease risk 00:24:30 - Lauren’s mother’s disease progression and the enormous stress it causes for family members 00:29:30 - The various manifestations of Alzheimer’s disease depending on the location of pathology 00:34:45 - The three stages of Alzheimer's disease 00:39:15 - Richard’s deep exploration into Lauren’s family history revealing clues about a diagnosis and a roadmap to successful disease mitigation 00:58:00 - How exercise reduces Alzheimer’s disease risk, and the different risk between males and females 01:08:00 - Why knowing your APOE status is important, and whether certain people should be wearier of head trauma 01:14:45 - How Richard uses genetic testing to personalize care 01:21:45 - The “ABCs” of Alzheimer’s prevention, lifestyle interventions, and Lauren’s personal protocol for reducing her risk 01:36:30 - Unique treatment for people with the ApoE4 variant 01:40:00 - Richard’s mixed opinion on CBD and THC as a tool for disease prevention 01:41:45 - Cognitive testing procedures, and how Lauren’s tests furthered her commitment to her disease prevention protocol 01:50:00 - The relevance of sense of smell and hearing in Alzheimer’s disease risk and prevention 01:57:30 - The emotional benefit of knowing you have control over your mental and physical health 02:00:15 - HFC—a charitable organization founded by Lauren and Seth https://peterattiamd.com/laurenmillerrogen-richardisaacson/ About: The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more. Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life). Learn more: https://peterattiamd.com/ Subscribe to receive exclusive subscriber-only content: https://peterattiamd.com/subscribe/ Sign up to receive Peter's email newsletter: https://peterattiamd.com/newsletter/ Connect with Peter on: Facebook: http://bit.ly/PeterAttiaMDFB Twitter: http://bit.ly/PeterAttiaMDTW Instagram: http://bit.ly/PeterAttiaMDIG Subscribe to The Drive: Apple Podcast: http://bit.ly/TheDriveApplePodcasts Overcast: http://bit.ly/TheDriveOvercast Spotify: http://bit.ly/TheDriveSpotify Google Play: http://bit.ly/TheDriveGooglePlay